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The Cytognosis Platform

A GPS for human health.

Every road trip needs four things: a map, a satellite signal, a coordinate for where you are, and directions for where to go next. Cytognosis builds the same four things for your biology. Cytoverse draws the map. Cytoscan is the satellite array that watches you. Cytostat is your live coordinate on that map. Cytopolis charts the route forward, years before symptoms would otherwise send you to a doctor.

GPS for human health
One person at the center, three role-labeled nodes radiating out: the map, the sensor, and the navigator, working as one system. This is an illustrative schematic, not a real map or measurement.
Reactive, today

“You have diabetes.”

Proactive, with Cytognosis

“Your metabolic coordinates are shifting. Adjust your circadian timing to restore your trajectory.”

The problem

The same label can hide different biology.

Same diagnosis, different biology
One shared diagnosis label branches into three distinct, evidence-linked biological subtypes, plus one honestly labeled group still being mapped. Two people can share a label and not share the biology underneath it. This is a static, illustrative schematic, not real patient data, and does not represent a diagnosis.

Two people can carry the same diagnosis and respond to completely different treatments, because the diagnosis describes a symptom, not a cause. Modern psychiatry has no routine way to measure the biology underneath a label, so care runs on trial and error instead of mechanism.

~1 in 3

patients respond to their first depression treatment, despite more than $22B in NIH depression research.

2–6 months

is how long each medication trial takes before anyone knows whether it worked.

21–33%

of patients need two to four trials before finding one that helps.

The fix, in one line

Biotyping resolves one label into the distinct, mechanism-linked patterns hiding inside it, so treatment can be matched to the biology in front of the clinician, not the average patient in the label.

These mechanisms are not neatly boxed by diagnosis either. The same underlying biological factors recur across labels, which is why a genuinely useful map has to work across diagnoses, not one disorder at a time. The reason this gap persists is not neglect: understanding an individual’s disease biology is not something a company can patent, so the step that would fix diagnosis is the step the market has the least incentive to build. That is the market failure Cytognosis exists to close as a nonprofit.

How it works

Four tiers, working as one loop.

Every GPS needs a map, satellites, a coordinate, and a navigator. Cytognosis builds the same four layers for your biology.

The map

Cytoverse turns a diagnosis into a precise position on a map of human biology.

Two people who share a label but not a cause finally look different on the map.

How this changes care today
  • Today: clinicians treat people who share a diagnosis as if they share a cause. Cytognosis: Cytoverse gives each person their own Universal Health Coordinates, precise enough to catch subtle shifts and track them over time.
  • Today: diagnosis relies on symptom clusters, with little insight into the biology driving them. Cytognosis: Cytoverse combines detailed health profiles with the genetic and cellular drivers behind them.
Cytoverse · coordinate atlas
A scatter health map on two continuous biological axes, immune and metabolic, with a population of illustrative points and one tracked position reached by a traced trajectory: a coordinate, not a category. Illustrative example, not real patient data.
The satellites

Cytoscan watches dozens of molecular signals at once, continuously.

A continuous sensor array, from validated wearables and consumer brain sensors to programmable molecular patches. Our sensors reset in under a minute, so they track biomarkers going down as well as up. Most sensors only see them go up.

How Cytoscan decides where to look
  1. Start wide. A broad, low-detail scan establishes a person’s general position on the map.
  2. Zoom in on what matters. That scan, combined with personal information like genetics, points to the signals worth a closer look.
  3. Go all the way down, only there. Cytoscan zooms to single-cell detail only at those spots, not everywhere.
  4. Keep adjusting. As health shifts over months and years, Cytoscan follows the story wherever it moves.
Your coordinate

Cytostat is your live position on the map, updated in real time.

Not a label you receive once, but a location with a direction of travel. You see the drift before any threshold is crossed, and you see whether a change is working within days.

Why this tier is new

Earlier versions of this platform had a map, satellites, and a navigator, but never named the thing being computed: your actual position. Cytostat fills that gap, and it is the value that changes minute to minute.

Visualization in progress. A dedicated Cytostat coordinate figure will be added in a follow-up design pass.

The navigator

Cytopolis turns those signals into a specific, personal next step.

Computed on a person’s own device, so their raw biology never has to leave their hands.

How this changes care today
  • Today: finding the right treatment often means trial and error, based on population averages. Cytognosis: Cytopolis matches interventions to each person’s specific biotype.
  • Today: clinical decisions mostly wait until a problem crosses a diagnostic threshold. Cytognosis: Cytopolis looks for change while it is still reversible, often years before a condition becomes permanent.
map sense locate navigate repeat
Why one scale is never enough

Biology hides at every scale. We look at all of them.

A genetic risk factor, a disrupted brain pathway, and a mood symptom can all trace back to the same underlying cause, but each one is invisible from a different angle. Cytognosis is built to bridge scales that are normally studied in isolation.

Biotypes across scales
Molecular, cellular, circuit, and behavioral signals each tell part of the story. Cytognosis reads all four scales together and converges them into one coherent, interpretable readout. Illustrative schematic, not real patient data.

Cellular data is the scarce scale: it exists almost only in postmortem brain tissue, so today it is only generated for a handful of disorders. Genomic, connectomic, and phenotypic data are far more available. Rather than wait for cellular data that mostly does not exist yet, Cytognosis estimates the cellular picture from the other scales, and checks that estimate against real tissue as it becomes available. No single scale would let us do that; only having all of them lets one scale fill in for another. This is an illustrative schematic, not real patient data.

Breadth, honestly shown

Fourteen disorders, curated for their biology, not just their name.

Four circuits recur across several of these disorders. Six of the fourteen have no brain region named in our current research, and we show that honestly rather than filling in a guess.

A labeled lateral-view brain illustration showing four transdiagnostic circuits The Cytognosis brand brain illustration in lateral (side) view: a stylized, translucent render with anterior (front) toward the left and the cerebellum and brainstem toward the lower right, overlaid with seven labeled regions in anatomically-informed relative position: dorsolateral prefrontal cortex (upper frontal), orbitofrontal cortex (lower frontal), ventromedial prefrontal cortex (lower frontal, medial), subgenual anterior cingulate (deep, below the genu of the corpus callosum), nucleus accumbens (deep, basal forebrain), amygdala (deep, medial temporal lobe), and caudate (deep, central dorsal striatum), connected by four lines representing named transdiagnostic circuits. Deep, non-surface structures carry a dashed halo. dlPFC OFC vmPFC sgACC NAc Amygdala Caudate
Hover or select a circuit, or click a disorder, to see its associated symptom domain.
Illustrative schematic, not an anatomical scan and not patient data. Regions are shown in anatomically-informed relative position; deep, non-surface structures (vmPFC, sgACC, NAc, amygdala, caudate) carry a dashed halo. Circuit-to-domain pairings are literature-informed associations, not confirmed one-to-one causes.
Depression Substance use Psychosis / mania (cellular) Anxiety (+ dissociation) Repetitive thoughts & behaviors No adult domain / pediatric-only
Major depressive disorder1,600
Alcohol use disorder1,399
Schizophrenia~1,038
Opioid use disorder887
Bipolar disorder620–675
Nicotine use disorder639
Cannabis use disorder518
Generalized anxiety disorder510
PTSD285
ADHD249
Autism spectrum disorder~131
Anorexia nervosa84
OCD78
Tourette syndrome68

Bar length shows postmortem brain-tissue donor count (NIH NeuroBioBank), the most complete dataset we have across all fourteen. Circuit assignment is shown only where the source research names one.

See the full multiscale map on Psychoverse .

Cytoscan in practice

Watching biology move, years before behavior shows it.

A worked, illustrative example using depression, showing Cytoscan’s adaptive sensing in action. Monitoring starts wherever it is easiest to reach, an accessible marker like blood BDNF. As that marker moves in a positive direction, attention does not stop there: it adaptively shifts deeper, first to the brain circuit linked to depression, then, over a longer horizon, to the genomic pattern underneath both.

A diagnosis is a threshold event: before it, the system reports nothing unusual; after it, everything changes at once. A trajectory model tracks the same signal as motion instead, revealing a prevention window that a single snapshot cannot show.

Cytoscan · continuous monitoring, years early
With continuous monitoring, a subtle shift is noticed years before it would otherwise surface. Without it, nothing is flagged until a diagnosis lands much later. Illustrative timelines, not a real measurement.
Cytoscan · worked example, adaptive panel
A closed loop with the platform’s navigator model: initialize a panel from priors, observe joint signal, form a ranked hypothesis, refine the panel to test it. Illustrative and non-diagnostic, not real patient data.
The first application

Psychoverse is the platform, built for the brain.

Psychoverse is what Cytoverse becomes when it is pointed at neuropsychiatry: the same map, sensor, and navigator idea, built out across genomic, cellular, connectomic, and phenotypic data for mental health. Psychoverse works across four kinds of data, genetic risk, brain and cell biology, brain-circuit activity, and everyday symptoms and behavior, fusing whichever are available for a person and estimating the rest.

Genomic

Inherited risk factors shared across labels.

Cellular

Brain and cell biology, where tissue allows.

Connectomic

Brain-circuit activity and connectivity.

Phenotypic

Everyday symptoms and behavior over time.

Research program

Psychoverse

Open, non-diagnostic research infrastructure for studying continuous phenotype dimensions across genomic, circuit, physiological, and behavioral signals.

  • Longitudinal context over static labels
  • Mechanism-linked, auditable research
  • Clear uncertainty and no clinical claims
Explore Psychoverse
Personal companion

Yar

A local-first, voice-aware cognitive companion for neurodivergent adults: capture, thought organization, flexible planning, and gentle self-understanding.

  • Private by default and consent-led
  • Adaptive, inspectable support
  • Roadmap shaped by community votes
Meet Yar
Vote on Yar Features Yar Early Access

How people interact with the platform. Psychoverse’s research map and Yar’s daily companion share the same interpretable coordinates underneath, so the interface always shows why a signal matters, not just that it moved. For the deeper, dedicated overview of this first application area, see neuropsychiatry at Cytognosis .